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Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia
- Author(s)
- 정현주
- Alternative Author(s)
- Hyun Joo Jung
- Advisor
- 박준은
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2020-08
- Language
- kor
- Alternative Abstract
- Aim: To improve survival in patients with glucocorticoid-resistant T-cell acute lymphoblastic leukemia (T-ALL), it is critical to develop new therapeutic strategies to overcome steroid resistance. Materials and Methods: Biochemical and molecular methodologies were used to evaluate whether tissue transglutaminase (TG2) confers steroid resistance in T-ALL. Results: T-ALL cells were found to express elevated levels of TG2. We went on to generate models of steroid-adaptedsubclonesofT-ALLcelllinesthatwerenotablylesssensitivetosteroidsthantheparental cells. The steroid-adapted subclones showed increased TG2 expression and nuclear factor-κB (NF-κB) activity compared to T-ALL parental cells. Inhibition of TG2 suppressed steroid resistance and improved steroid cytotoxicity in steroid-adapted subclones of T-ALL in association with reduced NF-κB activity. Conclusion: It is important to note that this study identified that possible changes in TG2 expression may serve as a new target aimed at overcoming steroid resistance in T-ALL.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
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