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높은 이완성을 갖는 새로운 시스템의 MR 조영제: 가돌리늄을 담지한 메조다공 실리카 코어/쉘
- Author(s)
- 김민정
- Advisor
- 김상욱
- Department
- 일반대학원 분자과학기술학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2012-02
- Language
- eng
- Alternative Abstract
- New system of gadolinium based nanoparticles for T1-MR contrast agents which have high T1-relaxivity was developed. It showed non-aggregated, biocompatible properties and no release of free Gd3+ ions. The structure of non-aggregated MSHS/Gd2O3@pAA system was elucidated by TEM and SEM. The specific relaxivities, r1 and r2 values, of the MSHS/Gd2O3@pAA are measured by 4.9T MR scanner, which are higher than those of the commercial Gadovist. Gd3+ ion releasing experiment was conducted by measuring an amount of leached Gd3+, which showed a trace of ions was released. The cytotoxicity of MSHS/Gd2O3@pAA was examined on MDA-MB 435S cells, which showed no appreciable toxicity in the cells.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Molecular Science and Technology > 3. Theses(Master)
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