repository
Adherence of Bisphosphonate and Decreased Risk of Clinical Vertebral Fracture in Osteoporotic Patients
- Subtitle
- A Propensity Score Matching Analysis
- Alternative Title
- 골다공증 환자에서 비스포스포네이트 약물 순응도에 따른 척추골절 위험 분석: 성향점수 매칭 분석으로
- Author(s)
- 김세희
- Advisor
- 이윤환
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2023-02
- Language
- eng
- Alternative Abstract
- Purpose: Bisphosphonate is associated with a decreased risk of clinical vertebral fractures due to osteoporosis. However, there are limited studies on how poor compliance with bisphosphonate affects the risk of vertebral fractures in a nationwide cohort. We aimed to evaluate whether adherence to bisphosphonate affects the risk of fracture in osteoporosis patients. <br>Methods: We used the data of the Korean National Health Insurance Service Senior Cohort. A total of 33,315 (medication possession ratio [MPR]: 50) osteoporosis patients were matched using the propensity score matching method: those who received low-dose bisphosphonate and those who received high-dose bisphosphonate. Twenty-two confounding variables, including age, socioeconomic status, medications prescribed, and underlying diseases that may affect the risk of fracture were adjusted for propensity score matching. <br>The risk of vertebral fracture was assessed by Cox proportional hazards regression. <br>Results: Patients with a higher MPR showed a decreased vertebral fracture risk than those with a lower MPR (MPR 50 = hazard ratio [HR]: 0.909, 95% confidence interval [CI]: 0.877–0.942, P < 0.001; MPR 70 = HR: 0.874, 95% CI: 0.838–0.913, P < 0.001; MPR 90 = HR: 0.822, 95% CI: 0.780–0.866, P < 0.001). MPR was associated with a decreased clinical vertebral fracture risk in both groups with or without history of fracture. In the subgroup analysis, MPR was associated with a decreased clinical vertebral fracture risk in women, in all age, with or without T2DM, and with or without hypertension. <br>Conclusion: Higher MPR is associated with a lower clinical vertebral fracture risk. Hazard ratio of MPR 50% was 0.909.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
-
- License
- STATISTICS
- Total Visit :4,802,163
- Total Download :2,077
- Today View :50,141
