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Clusterin이 TGF-β 신호전달 기전을 통해 색소형성과정에 미치는 영향
- Alternative Title
- Clusterin negatively regulates melanogenesis via the TGFβ receptor-Smad pathway.
- Author(s)
- 이지운
- Advisor
- 강희영
- Department
- 일반대학원 의생명과학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2017-02
- Language
- eng
- Keyword
- Melanogenesis; Melanocyte; Clusterin; Fibroblast-derived factor; TGF-β
- Alternative Abstract
- Clusterin has been known as a biomarker of aging and is highly induced in stressed and senescent cells. In this study, RNA sequencing analysis showed transcripts for clusterin were highly expressed in UV irradiated fibroblasts. A considerable increase of clusterin was detected in the culture medium. We found that the clusterin associates with solar elastosis and is overexpressed in the acutely UV-irradiated skin. To investigate the effect of clusterin on melanogenesis, normal human melanocytes were treated with conditioned media of fibroblasts infected with clusterin-lentivirus or sh-clusterin. It was found that clusterin inhibits melanogenesis through MITF/tyrosinase downregulation via TGF-β signaling. The findings suggest that clusterin inhibits melanogenesis and that it plays a role in controlling UV-induced pigmentary changes.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Biomedical Sciences > 3. Theses(Master)
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