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The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa
- Alternative Title
- 인승민
- Author(s)
- In, Seung Min
- Alternative Author(s)
- 인승민
- Advisor
- 김현준
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2013-02
- Language
- eng
- Keyword
- Electromagnetic fields; Ciliary motility; Mucociliary transport; Protein kinase C; Mobile phone
- Alternative Abstract
- The aim of this study was to investigate the effects of a 1.8 GHz continuous electromagnetic fields (EMF) on human nasal mucociliary transport and to determine the pathophysiology of ciliary beat frequency (CBF) during an EMF-induced change. Human nasal mucosa cells were exposed to a 1.8 GHz EMF (SAR= 1.0 W/kg), and CBF was analyzed using an optical flow technique with the peak detection method. The 1.8 GHz EMF-exposed group showed a decreased CBF when compared to the control group. In the cytotoxicity assay, the difference in survival rates was not found between the two groups. In the EMF-exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the EMF-induced decrease of CBF. The EMF-induced decrease of CBF was abolished by GF 109203X, a novel PKC (nPKC) isoform inhibitor, whereas the decrease was not attenuated by Gö-6976, a specific inhibitor of conventional PKC (cPKC) isoform. EMF may inhibit CBF via an nPKC-dependent mechanism. Therefore, we have confirmed that EMF could decrease CBF by increasing PKC activity.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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