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The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김현준 | - |
| dc.contributor.author | In, Seung Min | - |
| dc.date.accessioned | 2019-10-21T07:19:42Z | - |
| dc.date.available | 2019-10-21T07:19:42Z | - |
| dc.date.issued | 2013-02 | - |
| dc.identifier.other | 13577 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/18176 | - |
| dc.description | 학위논문(박사)아주대학교 일반대학원 :의학과,2013. 2 | - |
| dc.description.tableofcontents | ABSTRACT TABLE OF CONTENTS LIST OF FIGURES I. INTRODUCTION II. MATERIAL AND METHODS III.RESULTS IV.DISCUSSION V. CONCLUSION REFERENCES 국문요약 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa | - |
| dc.title.alternative | 인승민 | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | 인승민 | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2013. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 570804 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013577 | - |
| dc.subject.keyword | Electromagnetic fields | - |
| dc.subject.keyword | Ciliary motility | - |
| dc.subject.keyword | Mucociliary transport | - |
| dc.subject.keyword | Protein kinase C | - |
| dc.subject.keyword | Mobile phone | - |
| dc.description.alternativeAbstract | The aim of this study was to investigate the effects of a 1.8 GHz continuous electromagnetic fields (EMF) on human nasal mucociliary transport and to determine the pathophysiology of ciliary beat frequency (CBF) during an EMF-induced change. Human nasal mucosa cells were exposed to a 1.8 GHz EMF (SAR= 1.0 W/kg), and CBF was analyzed using an optical flow technique with the peak detection method. The 1.8 GHz EMF-exposed group showed a decreased CBF when compared to the control group. In the cytotoxicity assay, the difference in survival rates was not found between the two groups. In the EMF-exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the EMF-induced decrease of CBF. The EMF-induced decrease of CBF was abolished by GF 109203X, a novel PKC (nPKC) isoform inhibitor, whereas the decrease was not attenuated by Gö-6976, a specific inhibitor of conventional PKC (cPKC) isoform. EMF may inhibit CBF via an nPKC-dependent mechanism. Therefore, we have confirmed that EMF could decrease CBF by increasing PKC activity. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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