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Gangliosides 자극에 의한 신경소교세포의 형태학적 변화에서의 tubulin의 역할에 대한 연구
- Alternative Title
- Park Ji-young
- Author(s)
- 박지영
- Alternative Author(s)
- Park Ji-young
- Advisor
- 주 일 로
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2006-02
- Language
- eng
- Alternative Abstract
- In addition to functional changes, activated microglia undergo morphological changes from a resting, ramified morphology to an activated, amoeboid shape. Gangliosides, despite their role as microglial activators, induce microglial ramifications. To identify the cytoskeletal components involved in microglial ramification, we stimulated cells with gangliosides in the absence or presence of cytoskeletal inhibitors and examined the resultant morphological changes. While LPS-induced ameboid shapes were blocked by all inhibitors, actin inhitibors and microtubule inhibitor, Ganglioside-induced ramifications were blocked by either paclitaxel or nocodazole, inhibitors of microtubule, but not by cytochalasin B or latrunculin B, which are inhibitors of actin polymerization. In contrast to these morphological changes, iNOS expression was suppressed by both inhibitors of actin filament and inhibitors of microtubule. These results indicate that ganglioside-induced ramification is more dependent on tubulin than actin and that both of these cytoskeletal components are involved in iNOS expression.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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