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파킨슨병의 심장자율신경계와 혈관 내피기능의 역할
- Author(s)
- 윤정한
- Advisor
- 홍지만
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2019--2
- Language
- eng
- Alternative Abstract
- Cardiac autonomic function, assessed using heart rate variability (HRV) and cardiac iodine- 123-meta-iodobenzylguanidine (MIBG), is altered in Parkinson’s disease (PD) patients. In addition, vascular endothelial function, as measured by flow-mediated dilation (FMD), might play a role in the pathogenesis and progression of neurodegenerative disease. However, little is known about whether cardiac autonomic function might be used in the early diagnosis of Parkinson’s disease (PD), and the extent to which such alterations contribute to the neurodegenerative process is unclear. Further, the involvement of vascular endothelial function in PD remains to be clarified. The clinical significance of cardiac autonomic function in the diagnosis and prognosis of PD and the involvement of vascular endothelial function were investigated in this study. HRV was significantly lower in early PD. Higher HRV was associated with better cognitive function. A reduction in cardiac MIBG uptake was associated with subsequent increased risk of dementia. In addition, FMD was significantly lower in PD patients, and was negatively associated with levodopa treatment. Surgical deep brain stimulation reduced levodopa administration and improved motor disability and FMD. In conclusion, cardiac autonomic dysfunction occurs early in PD and is associated with subsequent risk of developing PD-associated dementia. Vascular endothelial function is also altered in PD and appears to be affected by chronic levodopa treatment.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
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