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성인 중증천식 환자에서 생체지표로서 혈청 EDN 수치의 유용성
- Alternative Title
- Youngsoo Lee
- Author(s)
- 이영수
- Alternative Author(s)
- Youngsoo Lee
- Advisor
- 박해심
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2019--2
- Language
- eng
- Alternative Abstract
- Background: Severe asthma is a refractory disease with complex and heterogeneous pathophysiologic mechanisms. Eosinophilic inflammation is considered a key component of severe asthma (SA). However, there has been no reliable biomarker representing the eosinophilic inflammation of SA. Objective: This study aimed to characterize the clinical features of SA and to evaluate whether serum eosinophil-derived neurotoxin (EDN) level may predict the eosinophilic inflammation of SA in adult asthmatics. Methods: Severe asthmatics (n = 235) and nonsevere asthmatics (n = 898) were enrolled from Ajou University Hospital, South Korea. Serum levels of EDN and periostin (type 2 inflammatory biomarkers) were measured using ELISA, and their association with clinical parameters was analyzed. Results: Severe asthmatics were older and had longer disease durations with significantly lower levels of FEV1% pred and methacholine PC20. Total eosinophil count (TEC) and sputum eosinophil count (%) were significantly higher in severe asthmatics than in nonsevere asthmatics. Serum EDN level and serum periostin level were significantly higher in severe asthmatics than in nonsevere asthmatics (P < 0.034 and P < 0.001, respectively). Correlations of serum EDN level to TEC (r = 0.319, P < 0.001) and to serum periostin level (r = 0.302, P < 0.001) were noted in total asthmatics. Conclusion: These findings suggest that serum EDN level can be a useful biomarker for predicting the phenotype of SA in adult asthmatics.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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