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성인 중증천식 환자에서 생체지표로서 혈청 EDN 수치의 유용성
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 박해심 | - |
| dc.contributor.author | 이영수 | - |
| dc.date.accessioned | 2019-04-01T16:41:13Z | - |
| dc.date.available | 2019-04-01T16:41:13Z | - |
| dc.date.issued | 2019--2 | - |
| dc.identifier.other | 28659 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/15031 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의학과,2019. 2 | - |
| dc.description.tableofcontents | I. Introduction II. Materials and Methods A. Study Subjects B. Measurement of Eosinophilic Biomarkers C. Statistical Analysis III. Results A. Demographic and Clinical Characteristics B. Associations between Clinical Parameters IV. Discussion V. Conclusion References 국문요약 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 성인 중증천식 환자에서 생체지표로서 혈청 EDN 수치의 유용성 | - |
| dc.title.alternative | Youngsoo Lee | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Youngsoo Lee | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2019. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 905450 | - |
| dc.identifier.uci | I804:41038-000000028659 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/common/orgView/000000028659 | - |
| dc.description.alternativeAbstract | Background: Severe asthma is a refractory disease with complex and heterogeneous pathophysiologic mechanisms. Eosinophilic inflammation is considered a key component of severe asthma (SA). However, there has been no reliable biomarker representing the eosinophilic inflammation of SA. Objective: This study aimed to characterize the clinical features of SA and to evaluate whether serum eosinophil-derived neurotoxin (EDN) level may predict the eosinophilic inflammation of SA in adult asthmatics. Methods: Severe asthmatics (n = 235) and nonsevere asthmatics (n = 898) were enrolled from Ajou University Hospital, South Korea. Serum levels of EDN and periostin (type 2 inflammatory biomarkers) were measured using ELISA, and their association with clinical parameters was analyzed. Results: Severe asthmatics were older and had longer disease durations with significantly lower levels of FEV1% pred and methacholine PC20. Total eosinophil count (TEC) and sputum eosinophil count (%) were significantly higher in severe asthmatics than in nonsevere asthmatics. Serum EDN level and serum periostin level were significantly higher in severe asthmatics than in nonsevere asthmatics (P < 0.034 and P < 0.001, respectively). Correlations of serum EDN level to TEC (r = 0.319, P < 0.001) and to serum periostin level (r = 0.302, P < 0.001) were noted in total asthmatics. Conclusion: These findings suggest that serum EDN level can be a useful biomarker for predicting the phenotype of SA in adult asthmatics. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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