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Stem cell properties of human fetal cartilage derived progenitor cells as a novel cell source of regenerative medicine
- Author(s)
- 김활란
- Advisor
- 민병현
- Department
- 일반대학원 분자과학기술학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2018-08
- Language
- eng
- Keyword
- Fetal cartilage derived progenitor cells; Self-renewal; colony formation ability; Senescence; Culture conditions
- Alternative Abstract
- Stem cells research in tissue engineering and regenerative medicine is likely to offer a second generation of therapy for clinical diseases that cannot be treated until now. The stem cells possess two properties, self-renewal and differentiation potential. Differentiation potential of stem cells is the ability to differentiate into specialized cells, in response to appropriate signals. Because of ability to differentiate into different types of functional cells. MSCs are especially the major stem cells for regenerative medicine about approximately 10 years. Because MSCs can be obtained from a variety of tissues.But during long term expansion in vitro, they have disadvantages in terms of decrease differentiation and self-renewal ability as well as characteristic changes of senescence. To application of stem cells in regenerative medicine, in vitro expansion is required to reach the large cell numbers and maintain their character are necessary in order to use the cells. To generate therapeutically safe and usable stem cell-derived products for clinical cell therapies, all animal-derived material must be eliminated from the establishment, culture, and differentiation steps. In the stem cell therapies, the animal-derived reagents was a limitation and risk so in the most researches xeno free conditions is the best choice that do not contain animal components. Elimination of animal components during the in vitro long-term expansion as well as differentiation of stem cells is necessary prior to application in cell therapy. Previously, we demonstrated that characteristics of human fetal cartilage-derived cells (H.FCPCs) as a stem cells in comparison with H.MSCs and young chondrocytes in terms of their proliferation ability and plasticity in vitro and in vivo . And we confirmed that it is a cell source with excellent colony forming ability and no tumorigenicity in vivo.(not published) As well as, H.FCPCs showed low toxicity and immune rejection when injected in a rat model, and the possibility of treatment of synovial arthritis was confirmed.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Molecular Science and Technology > 3. Theses(Master)
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