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CB1R에 의한 췌장 베타 새포의 사멸과 증식 조절
- Alternative Title
- Regulation of Apoptosis and Proliferation by Cannabinoids in Pancreatic Beta Cells: Involvement of Bcl-2 and Cyclin D2
- Author(s)
- Kim, Jihye
- Alternative Author(s)
- Jihye Kim
- Advisor
- 김욱
- Department
- 일반대학원 분자과학기술학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2015-08
- Language
- eng
- Keyword
- pancreatic beta-cell; cannabinoid receptor; diabetes
- Alternative Abstract
- Recent reports have shown that cannabinoid 1 receptors (CB1Rs) are expressed in pancreatic β cells, where they induce cell death by directly inhibiting activation of insulin receptor. Here I report that anti-apoptotic protein Bcl-2 and cell cycle regulator Cyclin D2 are involved in cannabinoid-induced β-cell death and growth arrest. Treatment of MIN6 and βTC6 cells with a synthetic CB1R agonist WIN55,212-2 leads to decrease in the expression of Bcl-2 and Cyclin D2, in turn inducing an arrest of the cell cycle in the G0/G1 phase and caspase-3-dependent apoptosis. Consistently, genetic deletion and pharmacological blockade of CB1Rs leads to increased β-cell survival and proliferation after injury due to increased levels of Bcl-2 and Cyclin D2. These findings provide evidence for involvement of Bcl-2 and Cyclin D2 in the regulation of β-cell survival and growth and will serve as a basis for developing new therapeutic interventions to enhance β-cell function and growth in diabetes.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Molecular Science and Technology > 3. Theses(Master)
- Files in This Item:
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