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MPEG-PCLA 블록 공중합체로 제조된 주사가능한 하이드로겔을 이용한 항암제 약물의 국소적 전달 조절
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kang, Yun Mi | - |
| dc.date.accessioned | 2018-11-08T07:56:21Z | - |
| dc.date.available | 2018-11-08T07:56:21Z | - |
| dc.date.issued | 2011-02 | - |
| dc.identifier.other | 11195 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/8677 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :분자과학기술학과,2011. 2 | - |
| dc.description.tableofcontents | List of Figures ⅰ List of Tables ⅳ Chapter Ⅰ. General introduction 1 Ⅰ.1. Definition and types of biodegradable polymer 2 Ⅰ.2. Characterization of biodegradable polymer for drug delivery system 4 Ⅰ.2.1. Aliphatic polyester 4 Ⅰ.2.2. Polyethylene glycol (PEG) 4 Ⅰ.2.3. Polycaprolactone (PCL) 4 Ⅰ.3. Injectable hydrogel for locally controlled drug delivery system 5 Ⅰ.4. Reference 8 Chapter Ⅱ. Injectable hydrogel based on biodegradable MPEG-b-(PCL-ran-PLLA) diblock copolymers for drug delivery system 10 Ⅱ.1. Introduction 11 Ⅱ.2. Experimental section 13 Ⅱ.2.1. Materials 13 Ⅱ.2.2. Characterization 13 Ⅱ.2.3. Synthesis of the MPEG-b-(PCL-ran-PLLA) diblock copolymer, C95L5 14 Ⅱ.2.4. Viscosity measurements 14 Ⅱ.2.5. In vivo injection 15 Ⅱ.2.6. Histological analysis 16 Ⅱ.2.7. Statistical analysis 17 Ⅱ.3. Results 18 Ⅱ.3.1. Synthesis and characterization of MPEG-b-(PCL-ran-PLLA) diblock copolymers 18 Ⅱ.3.2. Phase transition of diblock copolymer solutions 22 Ⅱ.3.3. In vitro incubation of diblock copolymer solutions at body temperature 24 Ⅱ.3.4. In vivo gelation and degradation 26 Ⅱ.3.5. In vivo immunogenicity of gels 28 Ⅱ.4. Discussion 31 Ⅱ.5. Conclusion 34 Chapter Ⅲ. Controlled delivery of antitumor agent from biocompatible and injectable in situ-forming gel based on MPEG-PCLA diblock copolymer 35 Ⅲ.1. Introduction 36 Ⅲ.2. Experimental section 38 Ⅲ.2.1. Synthesis of MPEG-PCL diblock copolymers 38 Ⅲ.2.2. Viscosity measurements 38 Ⅲ.2.3. In vitro Dox release 38 Ⅲ.2.4. Cytotoxicity studies 39 Ⅲ.2.5. In vivo tumor growth 40 Ⅲ.2.6. Histological analysis 41 Ⅲ.2.7. Statistical analysis 41 Ⅲ.3. Results 43 Ⅲ.3.1. Preparation of an injectable in situ-forming gel 43 Ⅲ.3.2. In vitro Dox release 45 Ⅲ.3.3. Antiproliferative effects of treatments 46 Ⅲ.3.4. Intratumoral injection 47 Ⅲ.3.5. Biodistribution of Dox 51 Ⅲ.3.6. Histology studies 54 Ⅲ.4. Discussion 57 Ⅲ.5. Conclusion 60 Reference 61 Abstract (in Korean) 68 List of publications 70 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | MPEG-PCLA 블록 공중합체로 제조된 주사가능한 하이드로겔을 이용한 항암제 약물의 국소적 전달 조절 | - |
| dc.title.alternative | Controlled Delivery of Antitumor Agent from Biocompatible and Injectable In Situ-Forming Gel based on MPEG-PCLA diblock Copolymer | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.department | 일반대학원 분자과학기술학과 | - |
| dc.date.awarded | 2011. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 569290 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011195 | - |
| dc.subject.keyword | Controlled Delivery of Antitumor Agent | - |
| dc.subject.keyword | MPEG-PCLA diblock Copolymer | - |
| dc.subject.keyword | 항암제 약물 | - |
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