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생동등체를 적용한 카페익 산 유사체 합성과
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 윤성화 | - |
| dc.contributor.author | 정효재 | - |
| dc.date.accessioned | 2018-11-08T07:49:34Z | - |
| dc.date.available | 2018-11-08T07:49:34Z | - |
| dc.date.issued | 2009-02 | - |
| dc.identifier.other | 9631 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/7490 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :분자과학기술학과,2009. 2 | - |
| dc.description.tableofcontents | Abbreviation 그림 및 테이블 목록 Bioisoster of Caffeic Acid: Syntheses and Antioxidant Activities of 1-Hydroxy-2-pyridone Analogues ----------------------- 1 국문 요약 ---------------------------------------------- 2 Ⅰ. 서론 ----------------------------------------------- 4 1. 항산화제의 특징 ------------------------------------ 4 2. 활성산소 ------------------------------------------- 11 3. 항산화제의 용도 ----------------------------------- 13 4. 생동등체(Bioisosterism) ----------------------------14 5. Phenolic 화합물의 항산화 효과 ----------------------16 Ⅱ. 신약 도안 ----------------------------------------- 17 Ⅲ. 결과 및 토의 -------------------------------------- 18 1. Chemistry --------------------------------------- 18 2. DPPH Radical Scavenging Activities ----------------- 29 Ⅳ. 실험방법 ----------------------------------------- 30 1. Chemistry ---------------------------------------- 30 2. DPPH Radical Scavenging Assay ----------------- 38 Ⅴ. 결론 --------------------------------------------- 39 Ⅵ. 참고문헌 ----------------------------------------- 40 Abstract --------------------------------------------- 49 Appendix -------------------------------------------- 50 | - |
| dc.language.iso | kor | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 생동등체를 적용한 카페익 산 유사체 합성과 | - |
| dc.title.alternative | Jung Hyo Jae | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Jung Hyo Jae | - |
| dc.contributor.department | 일반대학원 분자과학기술학과 | - |
| dc.date.awarded | 2009. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 567739 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009631 | - |
| dc.description.alternativeAbstract | Caffeic acid is a naturally occurring phenolic compound that is found in many fruits, vegetables, and herbs (e.g. sage), including coffee. Caffeic acid and its analogues have attracted much attention and have been studied in recent years because of their antiviral, anti-inflammatory, and neuroprotective properties, and their antioxidant effects. In particular, their antioxidative effects can be used for either the prevention of oxidative rancidity in foods or the treatment of diseases related to reactive oxygen species, such as stroke and Alzheimer’s diseases. However, since caffeic acid is not approved for direct use in food, due to it being a suspected human carcinogen based on testing in mice, there is still a need to develop an analogue that has similar biological properties. Bioisosterism is considered to be a powerful method for selecting molecular groups for drug design and lead-compound development. By the application of bioisosterism, we previously found that replacing the catechol moiety in dopamine with 1-hydroxy-2-pyridone analogues resulted in similar dopaminergic activity. Based on those results, we replaced the functional catechol moiety in caffeic acid with 1-hydroxy-2-pyridone systems whose isosteric and isoelectric character are considered to be equivalent. Therefore, they are interchangeable in terms of their contributions to biological activity. The antioxidant activities of the synthesized 1-hydroxy-2-pyridone analogues and caffeic acid were measured using the previously reported DPPH method, and the results are shown in Table 6. Although caffeic acid showed potent radical scavenging activity, the 1-hydroxy-2-pyridone analogues did not show any activity. These results clearly indicate that the antioxidant activity of caffeic acid is mainly attributed to the catechol moiety. In conclusion, two 1-hydroxy-2-pyridone analogues of caffeic acid were successfully synthesized from the corresponding methoxynicotinaldehydes and it was found that the analogues revealed no antioxidant activities. | - |
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- Graduate School of Ajou University > Department of Molecular Science and Technology > 3. Theses(Master)
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