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Stereoselective Total Syntheses of Tsaokopyranols (–)-E, (–)-L, (+)-M, (+)- Jughopnin J, and (–)-Engelheptanoxide A
- Author(s)
- 손유희
- Alternative Author(s)
- Yuhui Son
- Advisor
- 이동주
- Department
- 일반대학원 약학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2022-02
- Language
- eng
- Keyword
- (+)-Jughopnin J; (+)-Tsaokopyranol M; (–)-Engelheptanoxide A; (–)-Tsaokopyranol E; (–)-Tsaokopyranol L; Dehydrogenative cycloetherification; Diastereoselectivity; Natural Products; trans-2-Alkyl-6-aryl-3; 6-dihydro2H-pyran
- Alternative Abstract
- The stereoselective total syntheses of naturally occurring bioactive 2,6-epoxydiarylheptanoids tsaokopyranols (–)-E, (–)-L, (+)-M, (+)-jughopnin J, and (–)-engelheptanoxide A have been accomplished in 4–6 steps starting from a chiral epoxide utilizing dehydrogenative cycloetherification and epimerization of trans- to cis-2-alkyl-6-aryl-3,6-dihydro-2H-pyran framework as the key steps. The absolute configuration of natural tsaokopyranol L was revised.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Pharmacy > 3. Theses(Master)
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