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A Novel Application of Buprenorphine Transdermal Patch to Relieve Pain in the Knee Joint of Knee Osteoarthritis Patients
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 이숙영 | - |
| dc.contributor.author | 최종범 | - |
| dc.date.accessioned | 2022-11-29T02:33:04Z | - |
| dc.date.available | 2022-11-29T02:33:04Z | - |
| dc.date.issued | 2022-02 | - |
| dc.identifier.other | 31700 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/20563 | - |
| dc.description | 학위논문(박사)--아주대학교 일반대학원 :의학과,2022. 2 | - |
| dc.description.tableofcontents | I. 서론 1 II. 본론 3 1) Materials and Methods 3 2) Results 4 3) Discussion 7 III. 결론 8 VI. 참고문헌 8 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | A Novel Application of Buprenorphine Transdermal Patch to Relieve Pain in the Knee Joint of Knee Osteoarthritis Patients | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2022. 2 | - |
| dc.description.degree | Doctoral | - |
| dc.identifier.localId | 1244946 | - |
| dc.identifier.uci | I804:41038-000000031700 | - |
| dc.identifier.url | https://dcoll.ajou.ac.kr/dcollection/common/orgView/000000031700 | - |
| dc.subject.keyword | Buprenorphine | - |
| dc.subject.keyword | Knee | - |
| dc.subject.keyword | Knee Joint | - |
| dc.subject.keyword | Osteoarthritis | - |
| dc.subject.keyword | Transdermal Patch | - |
| dc.description.alternativeAbstract | Osteoarthritis (OA) is considered to be one of the most disabling diseases. The intra-articular opioid injection has been widely studied for its simplicity, safety, and efficacy in OA. In this study, however, we suggest a novel method of buprenorphine transdermal patch (BTDP) to painful knee joints of OA patients, instead of intra-articular opioid injection, and subsequently compared the knee application with conventional chest application. We retrospectively enrolled 213 patients with knee OA who did not respond to conventional therapy. The Numeric Rating Scale (NRS), adverse effects, and compliance were recorded before and after the application of the BTDP. All parameters were compared between the knee applied group and the chest applied group. After the BTDP application, the NRS score in the knee applied group was lower than that of the chest applied group (p = 0.007). NRS scores after buprenorphine patch decreased to 2.21 ± 0.77, and 2.55 ± 0.71 in the chest applied group and the knee applied group, respectively. The adverse effects were 19.32% in the knee applied group, and 64.00% in the chest applied group. The compliances were 82.95% and 37.60% in the knee applied group and chest applied group, respectively. This novel application of BTDP directly to the painful knee joint of knee OA patients led to a decrease in the NRS score, adverse effects, and an increase in compliance compared with the chest application method. | - |
| dc.title.subtitle | A Retrospective Case-Control Study | - |
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
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