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TSSK1β inhibits the Hippo pathway effector protein YAP to suppress cell proliferation
- Author(s)
- 최수희
- Alternative Author(s)
- Choi Sue-Hee
- Advisor
- 모정순
- Department
- 일반대학원 의생명과학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2021-08
- Language
- eng
- Keyword
- Cancer; Cell proliferation; Hippo pathway; LATS1/2; TEAD; TSSK1β; YAP
- Alternative Abstract
- The Hippo signaling pathway, which is involved in the regulation of cell proliferation, and an important tumor suppressor. The central regulators of the Hippo signaling pathway include the transcriptional co-activators YAP /TAZ which are negatively regulated by LATS1/2 kinases. The phosphorylation of YAP/TAZ promote their cytoplasmic sequestration where they bind with 14-3-3 protein or undergo proteasomal degradation. Dysregulation of Hippo pathway promotes the oncogenic properties of YAP/TAZ and improves cancer progression. However, the potential of YAP as a therapeutic target for cancer has not been well studied. To identify kinases-induced the phosphorylation of YAP, we screened diverse kinases which belong to CAMK family. This study demonstrated that TSSK1β promoted YAP phosphorylation partially through the LATS1/2-dependent or –independent mechanisms. Furthermore, TSSK1β consequently inhibits cell proliferation and anchorage-independent growth in LATS1/2 DKO MEFs. In summary, our findings suggest that TSSK1β can suppress YAP/TAZ-mediated cancer cell proliferation. Thus, TSSK1β can be a potential therapeutic target carcinogenesis.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Biomedical Sciences > 3. Theses(Master)
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