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Preparation and characterization of interpolyelectrolyte complex microcapsules for controlled perfume release
- Author(s)
- 이주현
- Advisor
- 이범진
- Department
- 일반대학원 약학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2021-02
- Language
- eng
- Alternative Abstract
- Although perfumes are used in various industries and daily life, they are limited in their use due to their high volatility and easy change due to exposure to the external environment. The purpose of this study was to design sustained release perfume with high encapsulation efficiency, using limonene (LMN) as a model perfume. Chitosan (CTS) has the properties of positive charge in aqueous solution, while Eudragit S100 (ES100) has the properties of the negative charge. Used the properties of these polymers, they formed interpolyelectrolyte complexes (IPECs) and improved LMN loaded efficiently and sustained release. The main method was formed to o/w emulsion using ultra-sonication, and microcapsule powder was manufactured using pH controlled and freeze-drying method. Encapsulation efficiency, loading content, and sustained release effect were evaluated using HPLC at different ratio of CTS and ES100 respectively. The tendency of release of LMN was measured by quantifying it at room temperature. And evaluated the physicochemical properties of LMN loaded capsules using DSC, FTIR, and CAS. The optimized capsule loaded with LMN showed 94% encapsulation efficiency and more than 120 hours of sustained effectiveness.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Pharmacy > 3. Theses(Master)
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