AJOU Central Library Repository: Effect of polymer types on the abuse deterrent narcotic formulation

Graduate School of Ajou University Department of Pharmacy 3. Theses(Master)

Effect of polymer types on the abuse deterrent narcotic formulation

Keyword: Abuse-deterrent index; Crush resistance; Dissolution profiles; Narcotic drug; Polymer type; Solvent extraction; Swellability

Alternative Abstract: Pharmaceutical strategies to design abuse-deterrent formulations (ADFs) should be considered by preventing the modification of physical and chemical properties of opioid dosage forms. Among these, four major properties such as particle size by physical modification, swellability, dissolution test and solvent extraction were mainly characterized for evaluating abuse deterrence. In this study, the frequently used eight polymers in the formulation of abuse-deterrent dosage forms such as polyvinyl alcohol (PVA), HPMC 90SH 4,000, HPMC 90SH 100,000, xanthan gum (XG), cellulose acetate (CA), polyethylene oxide (PEO), carbomer 940 and Compritol 888 ATO were chosen to evaluate their potential to prevent abuse of narcotic-loaded tablet. Tramadol (TM) was chosen as a model drug. A new abuse deterrent index (ADI) of TM-loaded compressed tablet was then defined on the assumption that it was proportional to particle size and swellability and inversely proportional to dissolution and solvent extraction rates. The chosen polymers could vary these physicochemical properties, giving ADI in a decreasing order: HPMC 90SH 4,000, Carbomer 940, Compritol, XG, PVA, HPMC 90SH 100,000, PEO and cellulose acetate. This study could provide a way to utilize different polymers for the prevention of drug abuse.

Appears in Collections:: Graduate School of Ajou University > Department of Pharmacy > 3. Theses(Master)

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