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국소 진행성 직장암에서 수술전 항암화학방사선치료 기간 동안의 말초혈액의 림프구 아형의 변화가 종양 반응에 미치는 영향
- Author(s)
- 허재성
- Advisor
- 오영택
- Department
- 일반대학원 의학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2017-02
- Language
- eng
- Keyword
- Rectal neoplasms; Immunity; Lymphocytes; NK cells
- Alternative Abstract
- Background: The aim of this prospective study was to evaluate the association between lymphocyte subpopulation counts in the blood during preoperative chemoradiotherapy (CRT) and tumor response in rectal cancer. Methods: From August 2015 to June 2016, 10 patients satisfying criteria for prospective study were enrolled. Patients received conventional radiotherapy with fluorouracil-based chemotherapy and surgery was performed at 4 to 8 weeks after end of preoperative CRT. The lymphocyte subpopulation was obtained prior to and after 4 weeks of preoperative CRT. We analyzed the relationship between a tumor response and host immunity such as lymphocyte subpopulation during preoperative CRT. Results: Among 10 patients, 2 (20%) had evidence of pathologic complete response. In 8 patients with clinically node positive, 4 (50%) had nodal tumor response. All lymphocyte subpopulation counts at 4 weeks after CRT were significantly lower than lymphocyte count observed during pretreatment (p < 0.01). A high decrease in NK cell count during CRT (baseline cell count − cell count at 4 weeks) was associated with node down staging (p = 0.034). Conclusions: Our results suggest that the change of lymphocyte subset to preoperative CRT may be a predictive factor for tumor response in rectal cancer.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Medicine > 4. Theses(Ph.D)
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