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인체 멜라닌 세포에서 Wnt 조절인자인 sFRP2와 WIF-1의 색소형성에 대한 역할
- Alternative Title
- Wnt Modulators, Secreted Frizzled Related Protein (sFRP) 2 and Wnt Inhibitory Factor (WIF)-1, Stimulate Melanogenesis in Normal Human Melanocytes
- Author(s)
- Kim misun
- Alternative Author(s)
- Misun Kim
- Advisor
- 강희영, 박태준
- Department
- 일반대학원 의생명과학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2016-08
- Language
- eng
- Keyword
- sFRP2; WIF-1; Hyperpigmentary disorder; Melasma; Melanocytes; Skin pigmentation
- Alternative Abstract
- Wnt signaling plays a role in the differentiation as well as the development of melanocytes. Previous studies showed that hyperpigmentary skins of melasma express high levels of frizzled-related protein 2 (sFRP2) and Wnt inhibitory factor-1 (WIF-1) compared to perilesional normal skins. In this study, I investigated the functional roles of sFRP2 and WIF-1 on skin pigmentation. The present study demonstrated that sFRP2 and WIF-1 were expressed in both melanocytes of normal human skin and in cultured melanocytes, suggesting that these molecules may have physiologic functions in melanocytes as an auto- or paracrine modulator of Wnt signaling. In addition, I found that secreted frizzled-related protein 2 (sFRP2) was overexpressed in the hyperpigmentary skins of not only melasma but also solar lentigo and the acutely UV-irradiated skin in vivo. Therefore, I hypothesized that sFRP2 and WIF-1 could have stimulatory roles for skin pigmentation. As results, sFRP2 and WIF-1 stimulated melanogenesis in normal human melanocytes through the increased expression of MITF and tyrosinase via β-catenin signaling. Moreover, the epidermal pigmentation of human skin was also increased in the presence of recombinant human sFRP2 and WIF-1. These findings suggest that UV irradiation may stimulate sFRP2 and WIF-1 secretion in the skin, which functions as melanogenic stimulator. This may play an important role in the development of UV-induced hyperpigmentary disorders.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Biomedical Sciences > 4. Theses(Ph.D)
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