폐경 후 골다공성 척추압박골절 환자의 유전자 다형 관련성

Alternative Title
Young Sun Chung
Author(s)
Chung, Young Sun
Alternative Author(s)
Young Sun Chung
Advisor
조기홍
Department
일반대학원 의학과
Publisher
The Graduate School, Ajou University
Publication Year
2011-08
Language
eng
Keyword
vascular endothelial growth factor (VEGF)osteoporotic vertebral compression fracturepostmenopausal womenpolymorphismhomocysteine
Alternative Abstract
Vascular endothelial growth factor (VEGF) is involved in bone formation through its role in angiogenesis. VEGF is also known to promote the healing of fractures and hyperhomocysteinemia is associated with the risk of skeletal health problems, such as osteoporosis, low body mineral density, and fracture. 5, 10-Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are involved in homocysteine metabolism. Thus, we determined whether or not VEGF, MTHFR, and TS polymorphisms are associated with osteoporotic vertebral compression fractures in postmenopausal Korean women. The study subjects consisted of 82 patients with osteoporotic vertebral compression fractures and 117 control postmenopausal Korean women. PCR-RFLP and real-time PCR assay were used to analyze VEGF, MTHFR, and TS polymorphisms. Homocysteine levels were also measured to determine whether or not polymorphisms of the VEGF gene affect homocysteine/folate metabolism. The AA genotype of the -2578C>A polymorphism were significantly different between the stroke and control groups; no significant differences in the -1154G>A, -634G>C, and 936C>T genotype frequencies existed. However, the A-G-G-C haplotype had a tendency to be associated with osteoporotic vertebral compression fractures in postmenopausal Korean women. Associations between the VEGF -2578C>A polymorphism and homocysteine levels were also noted. There was not significant association of MTHFR and TS polymorphisms with osteoporotic vertebral compression fractures. In summary, these results suggest that the VEGF -2578C>A polymorphisms and VEGF haplotypes may play an important role in the etiology of osteoporotic vertebral compression fractures in postmenopausal Korean women.
URI
https://dspace.ajou.ac.kr/handle/2018.oak/18016
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Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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