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Preparation and characterization of sustained release film and tablet using physicochemically modified rice starch
- Alternative Title
- Preparation and characterization of sustained release film and tablet using physicochemically modified rice starch
- Author(s)
- Kwon Soon Hyung
- Alternative Author(s)
- Kwon Soon Hyung
- Advisor
- 이범진
- Department
- 일반대학원 약학
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2016-02
- Language
- eng
- Keyword
- glutinous rice starch; thermally modified rice starch; spray-dried thermally modified rice starch; crosslinking; film; sustained release
- Alternative Abstract
- The aim of this study was to investigate a novel, biodegradable, spray-dried, thermally modified rice starch (SDTMR) as a film-forming agent and retardant polymer for preparing the solid dosage form. Films were prepared by the solvent casting method, and tablets were prepared by direct compression of drug-loaded powder. Sarpogrelate HCl was chosen as the model drug. Calcium chloride (CaCl2) and magnesium chloride (MgCl2) were utilized as crosslinking agents to obtain the desired effect. The size, surface morphology and crystallinity of starch powders (glutinous rice starch (GR), thermally modified rice starch (TMR) and SDTMR) were characterized by a particle size analyzer, scanning electron microscopy (SEM) and powder x-ray diffraction (PXRD). The surface morphology and roughness of the starch films were characterized by confocal laser scanning microscopy (CLSM). The tensile strength and elongation of the film were determined by a texture analyzer. The physical properties of tablets, such as weight, thickness and hardness were also measured. Swellability and erosion of the tablets were then analyzed by gravimetric evaluation. In vitro dissolution testing was performed in gastric fluid (pH 1.2 buffer) and intestinal fluid (pH 6.8 buffer). The crystallinity of TMR and SDTMR was transformed from the crystalline to the amorphous state. The SDTMR film had a smoother surface than the TMR and GR films. In pH 6.8 buffer, SDTMR film crosslinked with CaCl2 showed a significantly higher sustained drug release compared to SDTMR crosslinked with MgCl2. In conclusion, physicochemically modified rice starch provides a promising approach to prepare pharmaceutical film and tablets with sustained release.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Pharmacy > 3. Theses(Master)
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