Analyzing bilateral trade between Ghana and 90 countries, the study uses a panel setting of the difference-in-difference method (with heteroskedasticity-robust fixed effects) to estimate the impact of the trade policy (export-led industrialization policy) which was implemented in 2005 on exports and total trade. A chow test is conducted to confirm the presence of a structural break before and after the implementation of the trade policy. Considering the fact that only a few (about 5) bilateral trade agreements were concluded between Ghana and other countries, the study assumes a natural control for tariff reductions and focuses on other trade costs. The studies shows negative relationship between trade costs and exports and total trade, with the trade policy leading to increase in exports and expansion of trade. With increase in bilateral trade agreements leading to reduction in tariffs, this calls for a more important focus on other non-tariff measures and measures to improve value addition.