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기능화된 양친매성 블록 공중합체의 제조 및 온도감응성 하이드로젤 특성평가
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김문석 | - |
| dc.contributor.author | 이혜연 | - |
| dc.date.accessioned | 2018-11-08T08:12:18Z | - |
| dc.date.available | 2018-11-08T08:12:18Z | - |
| dc.date.issued | 2018-02 | - |
| dc.identifier.other | 27115 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/11653 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :분자과학기술학과,2018. 2 | - |
| dc.description.tableofcontents | CHAPTER 1. General introduction 1 1.1. Biomaterials 1 1.2. Functionalization of polyester 1 1.3. Biomedical applications 2 CHAPTER 2. Evaluation of ionic group-functionalized temperature-responsive hydrogels via electrostatic interaction 6 2.1. Introduction 6 2.2. Experimental section 11 2.3. Results and Discussion 18 2.4. Conclusion 39 CHAPTER 3. Temperature-responsive hydrogels via the electrostatic interaction of amphiphilic diblock copolymers with pendant-ion groups 40 3.1. Introduction 40 3.2. Experimental section 46 3.3. Results and Discussion 52 3.4. Conclusion 79 CHAPTER 4. Overall conclusion 80 REFERENCES 81 ABSTRACT (IN KOREAN) 92 LIST OF PUBLICATIONS 93 LIST OF PRESENTATIONS 95 LIST OF PATENTS 97 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 기능화된 양친매성 블록 공중합체의 제조 및 온도감응성 하이드로젤 특성평가 | - |
| dc.title.alternative | Synthesis and evaluation of pendant group-functionalized amphiphilic diblock copolymers as temperature-responsive hydrogels | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Hye Yun Lee | - |
| dc.contributor.department | 일반대학원 분자과학기술학과 | - |
| dc.date.awarded | 2018. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 800545 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000027115 | - |
| dc.subject.keyword | 온도감응성 하이드로젤 | - |
| dc.subject.keyword | 기능성 작용기 | - |
| dc.subject.keyword | 정전기적 상호작용 | - |
| dc.description.alternativeAbstract | Poly(ethylene glycol)-polyester diblock copolymers have been widely developed as temperature-responsive hydrogels due to their biodegradability and excellent biocompatibility. The polyester diblock copolymers have crystallinity due to the hydrophobic aggregation that enables sol-to-gel phase transition by temperature. However, polyester diblock copolymers have a critical limitation of the absence of suitable functionality, which may cause insufficient delivery of bioactive molecules such as drugs, peptides and hormones. In this study, polyester diblock copolymers with functionalizable pendant groups were prepared and evaluated as temperature-responsive hydrogels. In Chapter 2, functionalized monomer (CL-OBn) was synthesized and polymerized with ε-caprolactone (CL) by using methoxy polyethylene glycol (MPEG) in the presence of HCl·Et2O as a monomer activator. MPEG-b-poly(ε-caprolactone) (MC) with benzyl pendant groups (MC-OBn) was successfully obtained, and then deprotection of the benzyl groups provided MC with hydroxyl pendant groups (MC-OH). The sol-to-gel phase transition of the MC-OBn and MC-OH diblock copolymers was found to depend on the type and amount of pendant groups. In Chapter 3, we prepared MC with cationic (MC-NH2) and anionic (MC-COOH) pendant groups and evaluated the formation of temperature-responsive hydrogels via the electrostatic interaction of ionic pendant groups. The electrostatic interactions were confirmed by mixing the hydrogels of MC-COOH and MC-NH2 diblock copolymers. In addition, the suspensions of ionic hydrogel with counter ionic electrolytes exhibited sol-to-gel phase transition to depend on the identities and concentration of electrolytes as the crosslinking agent. In conclusion, polyester diblock copolymers with various pendant groups were successfully prepared and examined sol-to-gel phase transition by temperature. These results explain that the novel polyester diblock copolymers can be served as temperature-responsive hydrogels for biomedical applications. | - |
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- Graduate School of Ajou University > Department of Molecular Science and Technology > 3. Theses(Master)
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