The aim of this work is to investigate the determinants of bilateral trade flows between Cameroon and her top trading partners by considering trade data from 1995-2015. To do this we employ the augmented gravity model approach and panel estimation techniques which by its very usage provide theoretical justification for the Gravity model of trade. Our results reveal that Cameroon’s bilateral trade is affected positively by the size of its economy and that of its trading partner in terms of GDP, size of the market in terms of Population, and membership to common free trade agreements. Our results further reveal that transport cost proxied by distance negatively affects bilateral trade flows. Again we realize that levels of per capita income and resource endowments are not determinants of trade relations between Cameroon and her trading partners. Finally common language does not influence trade negatively or positively between trading partners for the case of Cameroon. The results provide important insights as to which direction Trade policies should take in order to take advantage of the country’s trade potential and hence increase economic growth and development.