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Preparation of nanoemulsions containing highly concentrated TECA using the phase―inversion temperature method
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 윤현철 | - |
| dc.contributor.author | 박병호 | - |
| dc.date.accessioned | 2022-11-29T03:01:14Z | - |
| dc.date.available | 2022-11-29T03:01:14Z | - |
| dc.date.issued | 2020-02 | - |
| dc.identifier.other | 29845 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/20913 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :응용생명공학과,2020. 2 | - |
| dc.description.tableofcontents | 1. Introduction 1.1 Centella asiatica 1 1.2 Dermal fibroblast 3 1.3 Phase-Inversion Temperature (PIT) Emulsification 5 1.4 Aim of the thesis 6 2. Material and Methods 2.1 Chemical and apparatus 7 2.2 PIT nanoemulsion manufacturing 8 2.3 Emulsifier and oil optimization 9 2.3.1 Confirmation of the formation of the PIT nanoemulsions with emulsifier and oil 9 2.3.2 Electrical conductivity measurements 9 2.3.3 Stability tests of the formulations (stored at 4, 25, 44, 50 °C) 10 2.4 Dissolution of TECA via a dissolution method 11 2.4.1 Dissolution of TECA using the PIT emulsification method 11 2.4.2 Dissolution of TECA using polyol 13 2.5 Particle size analysis of optimized nanoemulsions 13 2.6 Stability tests 14 3. Results and discussion 3.1 Determination of the optimal emulsifier and oil 15 3.1.1 PIT emulsification results for the POE oleyl ether series 15 3.1.2 PIT emulsification results for the POE decyltetradecyl ether series 18 3.1.3 PIT emulsification results for the POE glyceryl isostearate series 21 3.1.4 PIT emulsification results for the POE cetyl ether series 24 3.1.5 PIT emulsification results for the POE stearyl ether series 27 3.2 Dissolution of TECA via PIT emulsification 30 3.3 Dissolution of TECA using polyol 31 3.4 Particle size analysis of nanoemulsions containing TECA 32 3.5 Stability test 33 4. Conclusion 35 5. Reference 36 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | Preparation of nanoemulsions containing highly concentrated TECA using the phase―inversion temperature method | - |
| dc.title.alternative | BYEONGHO PARK | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | BYEONGHO PARK | - |
| dc.contributor.department | 일반대학원 응용생명공학과 | - |
| dc.date.awarded | 2020. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 1138575 | - |
| dc.identifier.uci | I804:41038-000000029845 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/common/orgView/000000029845 | - |
| dc.description.alternativeAbstract | The objective of this study was to develop a method for effectively dissolving titrated extracts of centella asiatica (TECA). TECA are known to be a wound-healing and wrinkle-reducing substance. However, TECA are insoluble, which makes them difficult to apply in cosmetics. Currently, polyol is commonly used as a solvent at high temperatures of 120 °C or more for dissolving ingredients to form a product. The main problems with such an approach is that a high temperature is required in the process and that the solvent must be heated directly, which means that there is a risk of fire. Moreover, there is a problem of re-precipitation over time. Therefore, the purpose of this study was to effectively dissolve TECA even at low temperatures of 80 °C or less by using the phase-inversion temperature (PIT) emulsification method. In order to select the optimal emulsifier and oil for the PIT emulsification method, 22 kinds of emulsifiers were used along with four kinds of oils (Mineral Oil, Caprylic/Capric Triglyceride (MCT), Hexyl Laurate, and Squalane). The water phase was fixed at 10% of purified water and 10% of glycerin. The oil phase was fixed at 10% of surfactant and 10% of oil, and the purified water was fixed to 50% as cooling water. Through an optimization approach, MCT and PEG (20) decyltetradecyl ether were found to yield the best results. TECA 0.5% was added to the formulation for optimization, and a control group was dissolved in the same amount of butylene glycol instead of the surfactant (15%) along with oil (10%) and glycerin (10%). Both the control and the experimental groups were stored at 4, 25, 44, and 50 °C to perform stability tests. The experimental group was stable, whereas the control group was found to have precipitated. | - |
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- Graduate School of Ajou University > Department of Applied Biotechnology > 3. Theses(Master)
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