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Effects of dasatinib on skin pigmentation
- Author(s)
- 강보경
- Alternative Author(s)
- Bogyeong Kang
- Advisor
- 강희영
- Department
- 일반대학원 의생명과학과
- Publisher
- The Graduate School, Ajou University
- Publication Year
- 2020-08
- Language
- eng
- Keyword
- Dasatinib; Differentiation; Melanocytes; Pigmentation
- Alternative Abstract
- Background: Dasatinib is a small molecule tyrosine kinase inhibitor that has activity against Src and c-Kit tyrosine kinases. Cases of dasatinib on skin pigmentation were examined have been reported. Objective The effects on dasatinib on skin pigmentation were examined. Methods: The effects on pigmentation were investigated by measuring melanin contents, tyrosinase activity and MITF and tyrosinase expressions in B16 melanoma cells and normal human melanocytes. The pigmentation were also assessed in the ex vivo skin. To explain the mechanism of dasatinib, ERK signaling pathway were examined. Results: Dasatinib treatment increased melanin contents and tyrosinase activity and MITF expression, which eventually led to pigmentation in melanocytes. The stimulatory action of dasatinib in pigmentation was further shown in ex vivo cultured skin. Furthermore, the molecular mechanism underlying the melanogenic effect of dasatinib was associated with the ERK-dependent phosphorylation of CREB. The ERK inhibitor PD98059 not only inhibited the phosphorylation of CREB but also abrogated dasatinib-induced melanocyte differentiation. Conclusion: Dasatinib induced skin pigmentation. These data suggest that dasatinib is a potential therapeutic for hypopigmentary disorders.
- Fulltext
- Appears in Collections:
- Graduate School of Ajou University > Department of Biomedical Sciences > 3. Theses(Master)
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