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백반증 환자에서 엑시머 레이저 치료의 연속 요법과 주기 요법의 효과 비교 연구
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 강희영 | - |
| dc.contributor.author | 성재민 | - |
| dc.date.accessioned | 2019-10-21T07:30:38Z | - |
| dc.date.available | 2019-10-21T07:30:38Z | - |
| dc.date.issued | 2017-08 | - |
| dc.identifier.other | 25498 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/19082 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의학과,2017. 8 | - |
| dc.description.tableofcontents | INTRODUCTION 1 MATERIAL AND METHODS 2 A. Study design and population 2 B. Treatment protocol 2 C. Assessment and primary outcome 2 D. Statistical analysis 3 RESULTS 4 A. Patient characteristics 4 B. Repigmentation rate of continuous and cyclic on-off excimer laser treatments 4 C. Clinical changes during intermission period in cyclic on-off protocol 7 DISCUSSION 8 CONCLUSION 10 REFERENCES 11 국문요약 13 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 백반증 환자에서 엑시머 레이저 치료의 연속 요법과 주기 요법의 효과 비교 연구 | - |
| dc.title.alternative | Efficacy of conventional continuous vs. cyclic on-off excimer laser treatment in vitiligo | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Jae Min Sung | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2017. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 788613 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000025498 | - |
| dc.subject.keyword | vitiligo | - |
| dc.subject.keyword | excimer laser | - |
| dc.subject.keyword | UVB treatment | - |
| dc.subject.keyword | cyclic treatment | - |
| dc.subject.keyword | melanocyte exhaustion | - |
| dc.description.alternativeAbstract | OBJECTIVE: To compare the efficacy of conventional continuous excimer laser treatment and cyclic on-off scheduled excimer laser treatment in vitiligo. DESIGN: A randomized, controlled, split-body, non-inferiority study. SETTING: The trial was performed in two tertiary health care centers in Korea. PARTICIPANTS: 12 patients (16 pairs of lesions) with bilateral and symmetrically distributed vitiligo and whose disease duration was less than 5 years. The patients taking systemic steroids or having enlarging lesions were excluded. All of 12 patients completed the study. INTERVENSIONS: All lesions were treated twice weekly by excimer laser for a total of 9-month trial period: continuously in group A, or cyclically with 2-month treatment and 1-month intermission every 3 month (total 3 cycles during the trial) in group B. Topical tacrolimus 0.1% ointment was equally applied to both groups throughout the trial. MAIN OUTCOMES AND MEASURES: Photographic documentation of lesions was conducted every month and the final degree of repigmentation of each group was assessed with a repigmentation rate (%) by using image analysis software. The non-inferiority margin was set at 10%. RESULTS: The mean difference of repigmentation rate between group A and B was 2.194% and the 95% confidence interval (-4.982% to 9.370%) was lower than the non-inferiority margin (10%). In group B, neither loss of repigmentation nor worsening of the vitiligo lesions was observed during intermission. CONCLUSIONS AND RELEVANCE: The cyclic on-off excimer laser treatment was as effective as the continuous excimer laser treatment in vitiligo. It can be a new treatment strategy for vitiligo without deteriorating the disease. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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