4시간 후 혈청 아밀라아제와 리파아제 농도를 이용한 내시경 역행성 췌담도 조영술 이후 췌장염 발생의 예측

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dc.contributor.advisor김진홍-
dc.contributor.authorLee, Yeon Kyung-
dc.date.accessioned2019-10-21T07:25:08Z-
dc.date.available2019-10-21T07:25:08Z-
dc.date.issued2015-08-
dc.identifier.other20149-
dc.identifier.urihttps://dspace.ajou.ac.kr/handle/2018.oak/18676-
dc.description학위논문(석사)--아주대학교 일반대학원 :의학과,2015. 8-
dc.description.tableofcontentsABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS CONCLUSION REFERENCE 국문요약-
dc.language.isoeng-
dc.publisherThe Graduate School, Ajou University-
dc.rights아주대학교 논문은 저작권에 의해 보호받습니다.-
dc.title4시간 후 혈청 아밀라아제와 리파아제 농도를 이용한 내시경 역행성 췌담도 조영술 이후 췌장염 발생의 예측-
dc.title.alternativePrediction of Post-ERCP Pancreatitis-
dc.typeThesis-
dc.contributor.affiliation아주대학교 일반대학원-
dc.contributor.alternativeNameYeon Kyung Lee-
dc.contributor.department일반대학원 의학과-
dc.date.awarded2015. 8-
dc.description.degreeMaster-
dc.identifier.localId705392-
dc.identifier.urlhttp://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020149-
dc.subject.keyword급성췌장염-
dc.subject.keyword내시경 역행성 췌담도 조영술-
dc.subject.keyword고아밀라아제혈증-
dc.description.alternativeAbstractBackground & Aims : Acute pancreatitis is the most common, serious complication of endoscopic retrograde cholangiopancreatography (ERCP). Early prediction of post-ERCP pancreatitis (PEP) could enable earlier safe discharge of patients on the same day after ERCP. This study investigated a predictive cut-off value of 4-hour post-ERCP serum amylase and lipase levels for PEP. Methods : We retrospectively evaluated patients who underwent ERCP procedures and testing for serum amylase and lipase 4-hours after ERCP and the next morning at Ajou Medical Center from January 2012 to August 2013. We studied; patient demographics, procedure reasons, pancreatogram performance, and serum amylase and lipase levels. Results : PEP occurred in 16 (3.1%) patients after 516 ERCP procedures. Its severity was mild in 4 (25%), moderate in 9 (56.3%), and severe in 3 (18.8%). Mean 4-hour amylase level was significantly higher in patients with PEP; than in those without (965 U/L vs. 158 U/L, P = .001). No statistically significant differences occurred in age, sex, and procedure reasons between both groups. Sensitivity, specificity and negative predictive value (NPV) of 4-hour post-ERCP amylase level with a cut-off value of 2.5x upper limit of reference (ULR) (290 U/L) were 39.1%, 98.5% and 97.2%, respectively; with a cut-off value of 8× ULR (480 U/L), they were 60.0%, 97.5% and 99.6%. The patient group undergoing pancreatogram had a high incidence of PEP; but no significant difference in 4-hour post-ERCP serum amylase and lipase, compared with its counterpart. Conclusions : Four-hour post-ERCP serum amylase and lipase levels with cut-off values of 2.5x and 8x ULR are proven useful predictive values for earlier safe discharge of patients on the same day after ERCP.-
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Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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