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비전이 투명 신세포암 환자의 수술 전 호중구/림프구 비율과 혈소판/림프구 비율의 예후적 중요도
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김선일 | - |
| dc.contributor.author | Lee, Jung Hwan | - |
| dc.date.accessioned | 2019-10-21T07:25:07Z | - |
| dc.date.available | 2019-10-21T07:25:07Z | - |
| dc.date.issued | 2015-08 | - |
| dc.identifier.other | 20339 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/18675 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의학과,2015. 8 | - |
| dc.description.tableofcontents | Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 2 Ⅲ. RESULTS 3 Ⅳ. DISCUSSION 11 Ⅴ. CONCLUSION 13 REFERENCES 14 국문요약 18 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 비전이 투명 신세포암 환자의 수술 전 호중구/림프구 비율과 혈소판/림프구 비율의 예후적 중요도 | - |
| dc.title.alternative | Prognostic significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with non-metastatic clear cell renal cell carcinoma | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2015. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 705094 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020339 | - |
| dc.subject.keyword | 신장암 | - |
| dc.subject.keyword | 염증 | - |
| dc.subject.keyword | 예후 인자 | - |
| dc.description.alternativeAbstract | Prognostic significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with non-metastatic clear cell renal cell carcinoma Introduction & Objectives: This study was performed to evaluate the significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as a predictive factor for recurrence in patients with non-metastatic clear cell renal cell carcinoma (RCC). Material & Methods: We retrospectively reviewed the medical records of 341 patients (232 men and 109 women, mean age of 54.9 years) with non-metastatic clear cell RCC who underwent radical or partial nephrectomy between March 1995 and July 2012. Patients longer than 12 months follow-up were included. The prognostic significance of various clinicopathological variables for recurrence-free survival and cancer specific-free survival was analyzed by using univariate and multivariate analysis. Results: The median follow-up duration was 48 months (mean, 54.1; range, 12-215 months). Of the total 341 patients, 37 patients (10.9%) developed metastases and 14 patients (4.1%) died of renal cell carcinoma among 21 patients who died during the follow-up period. Preoperative NLR was significantly correlated with symptom presentation (p=0.008), tumor size (p=0.022), T stage (p=0.004), neutrophil count (p<0.001), lymphocyte count (p<0.001), recurrence at follow-up (p=0.006). Preoperative PLR was significantly correlated with symptom presentation (p<0.001), lymphocyte count (p<0.001), recurrence at follow-up (p=0.002). In the univariate analysis, clinical presentation, tumor size, T stage, Fuhrman grade, preoperative hemoglobin, neutrophil count, NLR, PLR were significant prognostic factors for recurrence-free survival. The 5-year recurrence-free survival rate of patients with a higher preoperative NLR (≥2.5) was significantly lower than that of patients with a lower preoperative NLR (<2.5) (86.5% vs. 96.7%, p=0.006). The 5-year recurrence-free survival rate of patients with a higher preoperative PLR (≥130) was significantly lower than that of patients with a lower preoperative PLR (<130) (89.4% vs. 96.8%, p=0.022). In the multivariate analysis, tumor size (p<0.001), T stage (p<0.001), Fuhrman grade (p=0.015) and preoperative hemoglobin (p=0.026) were independent prognostic factors for recurrence-free survival. Conclusions: An increased preoperative NLR and PLR were associated with a higher recurrence rate in patients with non-metastatic clear cell RCC, although it was not an independent prognostic factor for recurrence-free survival. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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