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국소 트라넥삼산 도포에 의한 기미 치료에 대한 연구
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 강희영 | - |
| dc.contributor.author | Kim, Sang jin | - |
| dc.date.accessioned | 2019-10-21T07:24:10Z | - |
| dc.date.available | 2019-10-21T07:24:10Z | - |
| dc.date.issued | 2015-02 | - |
| dc.identifier.other | 19421 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/18585 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의학과,2015. 2 | - |
| dc.description.tableofcontents | ABSTRACT i TABLE OF CONTENTS ii LIST OF FIGURES iv LIST OF TABLES v I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. Subjects 3 B. Protocol of topical TA application 3 C. Assessment of TA treatment efficacy 3 D. Histopathological and immunohistochemistrical analysis 4 E. Image analysis 5 F. Statistical analysis 6 III. RESULTS 7 A. Clinical assessment of TA treatment efficacy 7 1. Clinical photographs 7 2. Melasma severity scale (MSS) 7 3. Modified melasma area and severity index (mMASI) 8 4. Chromameter 9 5. Subjective satisfaction score 10 B. Histological analysis 11 1. Pigmentation 11 2. Vascularity 11 3. Mast cell 13 4. Other immunohistochemical results 14 IV. DISCUSSION 20 V. CONCLUSION 23 REFERENCES 24 SUPPLEMENTS 27 국문요약 31 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 국소 트라넥삼산 도포에 의한 기미 치료에 대한 연구 | - |
| dc.title.alternative | Sang Jin Kim | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Sang Jin Kim | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2015. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 695480 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000019421 | - |
| dc.subject.keyword | Melasma | - |
| dc.subject.keyword | Topical tranexamic acid | - |
| dc.subject.keyword | Pigmentation | - |
| dc.subject.keyword | Vascularity | - |
| dc.subject.keyword | ET-1 | - |
| dc.subject.keyword | SCF | - |
| dc.description.alternativeAbstract | Background and Objectives: Melasma is an acquired hyperpigmentary disorder mainly on the face. Tranexamic acid (TA), a plasmin inhibitor, has been suggested as an efficient treatment modality on melasma. The aim of this study was to investigate the effects and action mechanism of topical TA in the treatment of melasma. Material and methods: Twenty three healthy Korean females with melasma were enrolled, and applied 2% TA formulation on the whole face for 12 weeks. Pigmentation and erythema were objectively assessed using melasma severity scale (MSS), modified melasma area and severity index (mMASI), and chromameter. The subject satisfaction questionnaire was also documented. Skin biopsies were obtained from 10 subjects on baseline and 12 weeks after treatment. Histological and immunohistochemical analyses were performed. Results: After 12 weeks, significant improvement in MSS and mMASI showed in 22 of 23 patients. L* values were increased in both lesional and perilesional normal skin after 12 weeks. The improvement was noticed in 4 weeks. a* values were decreased in both lesional and perilesional normal skin. Subjective satisfaction score was improved. Fontana-Masson staining showed significant decrease of pigmentation in both lesional and perilesional normal skin after treatment. There were no changes in vascularity and number of mast cells. ET-1 expression was significantly decreased in the epidermis of both lesional and perilesional normal skin after treatment. SCF expression in the epidermis was significantly decreased in the lesional skin after treatment. There were no changes in expressions of α-MSH, EP2, and VEGF. Conclusion: Topical TA improved pigmentation and erythema in melasma. Decreased expression of ET-1 and SCF in the epidermis after treatment was suspected to be an action mechanism of topical TA for melasma treatment. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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