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방사성 요오드 치료를 받은 분화성 갑상선암 환자의
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 윤준기 | - |
| dc.contributor.author | Jo, Kyung Sook | - |
| dc.date.accessioned | 2019-10-21T07:23:12Z | - |
| dc.date.available | 2019-10-21T07:23:12Z | - |
| dc.date.issued | 2014-08 | - |
| dc.identifier.other | 17394 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/18422 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의학과,2014. 8 | - |
| dc.description.tableofcontents | ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. Introduction 1 Ⅱ. Materials and Methods 4 A. Subjects 4 B. Radioiodine Treatment Protocol 5 C. Acquisition and Image Analysis of Salivary Gland Scintigraphy 6 D. Acquisition and Image Analysis of 131I Whole-Body Scintigraphy 8 E. Statistical Analysis 9 Ⅲ. Results 10 A. Characteristics of Patients 10 B. Salivary Gland Function 11 C. Radioiodine Retention on 131I Whole-Body Scintigraphy 12 D. Relation between Radioiodine Retention and Salivary Gland Function 13 Ⅳ. Discussion 16 V. Conclusion 22 References 23 국문요약 26 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 방사성 요오드 치료를 받은 분화성 갑상선암 환자의 | - |
| dc.title.alternative | Kyung Sook Jo | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Kyung Sook Jo | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2014. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 652641 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017394 | - |
| dc.subject.keyword | Radioiodine therapy | - |
| dc.subject.keyword | Salivary gland dysfunction | - |
| dc.subject.keyword | Differentiated thyroid cancer | - |
| dc.subject.keyword | I-131 scintigraphy | - |
| dc.subject.keyword | Salivary gland scintigraphy | - |
| dc.description.alternativeAbstract | - ABSTRACT - Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma Purpose: We investigated whether 131I whole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy. Methods: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after total thyroidectomy. All patients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups: a DWS+or DWS-group and a TWS+or TWS-group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak uptake and %washout were calculated in ROIs of each gland. Functional changes (Δuptake or Δwashout) of salivary glands after radioiodine therapy were compared between the two groups. Results: Both peak uptake and the %washout of the parotid glands were significantly lower after radioiodine therapy (all p values <0.001), whereas only the %washout were significantly reduced in the submandibular glands (all p values <0.05). For the parotid glands, the TWS+ group showed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (all p values >0.05). Likewise, no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS- groups in either the parotid or submandibular glands (all p values >0.05). Conclusion: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotid glands after high-dose radioiodine therapy. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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