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관상동맥 경화반 구성 요소의 용적 전형적인 심혈관 위험 요인과 대사 증후군과의 관계
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 탁승제 | - |
| dc.contributor.author | Zheng, Mingri | - |
| dc.date.accessioned | 2019-10-21T07:19:05Z | - |
| dc.date.available | 2019-10-21T07:19:05Z | - |
| dc.date.issued | 2011-08 | - |
| dc.identifier.other | 11901 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/18104 | - |
| dc.description | 학위논문(박사)아주대학교 일반대학원 :의학과,2011. 8 | - |
| dc.description.tableofcontents | ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅴ LIST OF TABLES ⅵ ABBREVIATIONS ⅶ I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. MATERIALS 3 1. Study population 3 2. Definition of the risk factors 3 B. METHODS 4 3. IVUS imaging and analysis 4 4. Statistical analysis 6 III. RESULTS 8 A. The baseline clinical and VH-IVUS characteristics 8 B. IVUS and VH-IVUS findings according to the classical risk factors and the metabolic risk factors associated to metabolic syndrome 11 C. Multivariate analysis of the risk factors for the plaque burden, the %NC and the VH-TCFAs 20 IV. DISCUSSION 22 V. STUDY LIMITATION 27 VI. CONCLUTION 29 REFERENCES 30 국문요약 36 LIST OF FIGURES Fig. 1. VH-TCFAs in regard to being with or without risk factors 19 Fig. 2. The correlation between the plaque components and the metabolic syndrome scores | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 관상동맥 경화반 구성 요소의 용적 전형적인 심혈관 위험 요인과 대사 증후군과의 관계 | - |
| dc.title.alternative | Zheng Mingri | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Zheng Mingri | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2011. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 569800 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011901 | - |
| dc.subject.keyword | virtual histology intravascular ultrasound | - |
| dc.subject.keyword | cardiovascular risk factors | - |
| dc.subject.keyword | coronary artery disease | - |
| dc.subject.keyword | imaging | - |
| dc.subject.keyword | plaque vulnerability | - |
| dc.description.alternativeAbstract | Objectives: The aim of this study was to analyze volumetric plaque composition of the coronary arterial tree according to the classical cardiovascular risk factors and metabolic syndrome (MS) by using virtual histology-intravascular ultrasound (VH-IVUS). Background: It remains unclear how the cardiovascular risk factors correlate with the histological components of coronary plaques. Methods: “Whole vessel” VH-IVUS analysis was performed in 189 vessels of 63 patients. The components of atherosclerotic plaques were classified as fibrous, fibrofatty, necrotic core (NC), and dense calcium. Quantitative assessment of these plaque components and the presence of VH-IVUS-derived thin-cap fibroatheroma (VH-TCFA) in the coronary arterial trees were compared to cardiovascular risk factors. Results: There was a significantly larger mean plaque+media (P+M) burden in patients with diabetes mellitus (DM) (47±5 vs. 39±7% in non-DM patients, p<0.001) and MS (47±4 vs. 39±7% in non-MS patients, p<0.001). DM patients had a significantly larger %NC (17.8±5.6 vs. 12.5±6.1, p=0.003) compared to non-DM patients; and MS patients had a significantly larger %NC (17.3±5.8 vs. 12.8±6.2, p=0.016) as compared to non-MS patients. Finally, VH-TCFAs were more frequent in DM patients (3.4±2.0 vs. 2.1±1.7 in non-DM patients, p=0.016) and in MS patients (4.1±2.1 vs. 1.9±1.4 in non-MS patients, p=0.001). Conclusions: Three-vessel VH-IVUS analysis showed that DM and MS patients had a larger P+M burden, larger amount of NC, and more frequent VH-TCFAs in coronary arterial trees compared to patients without DM or MS implying greater plaque vulnerability in DM and MS patients. | - |
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