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자궁내막암과 난소암에서 Syndecan-1의 암발생 효과와 Oleanolic acid 3-acetate의 항암효과를 확인하기 위한 in vitro와 in vivo 실험연구
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Oh, Jeong-Hyun | - |
| dc.date.accessioned | 2019-10-21T07:18:21Z | - |
| dc.date.available | 2019-10-21T07:18:21Z | - |
| dc.date.issued | 2012-08 | - |
| dc.identifier.other | 12925 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/17978 | - |
| dc.description | 학위논문(박사)아주대학교 일반대학원 :생명과학과,2012. 8 | - |
| dc.description.tableofcontents | CHAPTER1. 7 1.1. INTRODUCTION 8 1.2. MATERIALS AND METHODS 11 1.3. RESULTS 15 1.3.1. Overexpression of syndecan-1 leads to enhanced cell survival and proliferation 15 1.3.2. Overexpression of syndecan-1 leads to the activation of NF-κB 16 1.3.3. Overexpression of syndecan-1 enhances endometrial cancer invasion 16 1.3.4. Expression of integrin subunit αν and β5, and phosphorylation of FAK are enhanced in syndecan-1 overexpression 16 1.3.5. Overexpression of syndecan-1 induces expression of MMP-9 by the transactivation of NF-κB 17 1.4. DISCUSSION 19 1.5. REFERENCES 22 1.6. FIGURE LEGENDS 29 CHAPTER2. 43 2.1. INTRODUCTION 44 2.2. MATERIALS AND METHODS 47 2.3. RESULTS 51 2.3.1. Syndecan-1 promotes endometrial tumor growth in xenograft 51 2.3.2. Syndecan-1 promotes angiogenesis and MMP activation in endometrial tumors 52 2.4. DISCUSSION 53 2.5. REFERENCES 57 2.6. FIGURE LEGENDS 61 CHAPTER3. 70 3.1. INTRODUCTION 71 3.2. MATERIALS AND METHODS 74 3.3. RESULTS 80 3.3.1. Oleanolic acid 3-acetate treatment inhibits the growth of human tumor cell lines 80 3.3.2. Oleanolic acid 3-acetate induces AIF translocation into the nucleus 80 3.3.3. Oleanolic acid 3-acetate induces membrane alterations in SKOV3 and HEC-1A cells by combination of Annexin V binding and PI exclusion 81 3.3.4. Oleanolic acid 3-acetate induces the loss of ψm in SKOV3 and HEC-1A cells 81 3.3.5. Oleanolic acid 3-acetate induces the reduction of intracellular ROS in SKOV3 and HEC-1A cells 82 3.3.6. Oleanolic acid 3-acetate activates the mitochondrial apoptosis pathway and down-regulates proteins in the mitogen-activated protein kinase pathway 83 3.3.7. Oleanolic acid 3-acetate inhibits the proliferation of SKOV3 xenografts 84 3.4. DISCUSSION 86 3.5. REFERENCES 90 3.6. FIGURE LEGENDS 98 3.7. TABLE LEGENDS 109 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 자궁내막암과 난소암에서 Syndecan-1의 암발생 효과와 Oleanolic acid 3-acetate의 항암효과를 확인하기 위한 in vitro와 in vivo 실험연구 | - |
| dc.title.alternative | Jeong-Hyun Oh | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Jeong-Hyun Oh | - |
| dc.contributor.department | 일반대학원 생명과학과 | - |
| dc.date.awarded | 2012. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 570348 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012925 | - |
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