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자궁내막증식증 및 자궁내막암과 syndecan-1의 발현과의 관련성
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유희석 | - |
| dc.contributor.author | Kim Hyunjin | - |
| dc.date.accessioned | 2019-10-21T07:14:20Z | - |
| dc.date.available | 2019-10-21T07:14:20Z | - |
| dc.date.issued | 2010-08 | - |
| dc.identifier.other | 10928 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/17626 | - |
| dc.description | 학위논문(박사)--아주대학교 일반대학원 :의학과,2010. 8 | - |
| dc.description.tableofcontents | ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. INTRODUCTION 1 Ⅱ. PATIENTS AND METHODS 3 A. Patients and tissue samples 3 B. Immunohistochemical study 5 C. Staining evaluation 5 D. Statistical analysis 6 Ⅲ. RESULTS 7 A. Patient characteristics 7 B. Expression of syndecan-1 8 Ⅳ. DISCUSSION 12 REFERENCE 15 국문요약 19 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 자궁내막증식증 및 자궁내막암과 syndecan-1의 발현과의 관련성 | - |
| dc.title.alternative | The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Hyunjin Kim | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2010. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 568747 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928 | - |
| dc.subject.keyword | Syndecan-1 | - |
| dc.subject.keyword | 자궁내막증식증 | - |
| dc.subject.keyword | 자궁내막암 | - |
| dc.description.alternativeAbstract | Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p < 0.001). Syndecan-1 expression was significantly greater in CH (p < 0.001) or AH (p < 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p < 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer. | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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