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한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 김건영 | - |
| dc.date.accessioned | 2019-10-21T07:14:06Z | - |
| dc.date.available | 2019-10-21T07:14:06Z | - |
| dc.date.issued | 2010-08 | - |
| dc.identifier.other | 10922 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/17581 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의생명학과,2010. 8 | - |
| dc.description.tableofcontents | 국문요약 ················································································· ⅰ 차 례 ················································································· ⅳ 그림차례 ················································································· ⅵ 표 차례 ················································································· ⅶ Ⅰ. 서 론 ·················································································· 1 Ⅱ. 재료 및 방법 ········································································ 5 A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5 1. 루푸스 환자군과 대조군 ····················································· 5 2. 환자군과 대조군으로부터 채혈 ············································· 5 3. Genomic DNA 추출 ························································ 5 B. 단일염기다형성 탐색 ····························································· 5 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5 2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6 C. 단일염기다형성의 유전자형 결정 ·············································· 7 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7 E. 통계분석 ··········································································· 8 Ⅲ. 결 과 ················································································· 9 A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9 1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9 2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10 3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10 B. 다형성의 유전자형 결정 ······················································· 11 1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11 C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15 D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17 Ⅳ. 고 찰 ················································································· 19 Ⅴ. 결 론 ················································································ 22 참고 문헌 ················································································ 23 영문요약 ·················································································· 30 | - |
| dc.language.iso | kor | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성 | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Kim Keonypung | - |
| dc.contributor.department | 일반대학원 의생명과학과 | - |
| dc.date.awarded | 2010. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 568674 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922 | - |
| dc.subject.keyword | Fcγ 수용체 | - |
| dc.subject.keyword | 다형성 | - |
| dc.subject.keyword | 전신성 홍반성 루푸스 | - |
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