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단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 손성향 | - |
| dc.contributor.author | 심주아 | - |
| dc.date.accessioned | 2019-10-21T07:13:59Z | - |
| dc.date.available | 2019-10-21T07:13:59Z | - |
| dc.date.issued | 2009-02 | - |
| dc.identifier.other | 9672 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/17560 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :의생명학과,2009. 2 | - |
| dc.description.tableofcontents | ABSTRACT TABLE OF CONTENTS LIST OF FIGURE LIST OF TABLES Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS A. Antibodies and reagents B. Animal experiments C. BD-like symptoms D. Flow cytometry E. Splenocyte culture and generation of Treg cells F. Dendritic cells isolation and culture G. Co-culture of CD4+T cells with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice compared to BDN mice B. CD4+CD25+T cells were amplified in primary cultures of spleen tissues C. CD4+T cells from normal, BDN, and BD-like splenocytes were co-cultured with normal dendritic cells from normal mice D. Adoptive transfer with CD4+CD25+T cells up-regulated the frequencies of T cell in BD-like mice E. Change of symptoms in BD-like mice after adoptive transfer F. The change of severity score in transferred with CD4+CD25+T cells to BD-like mice G. CD4+CD25+T cells transfer up-regulated serum IL-10 and TGF-β levels and down-regulated IFN-γ and TNF-α levels H. Serum IL-6 and IL-17 levels were down-regulated after transfer I. The differences of serum cytokine amounts between the average of not transferred BD-like mice and 3x10^5 CD4+CD25+T cells transferred each BD-like mouse Ⅳ. DISCUSSION Ⅴ. CONCLUSION REFERENCES 국문요약 | - |
| dc.language.iso | kor | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할 | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.department | 일반대학원 의생명과학과 | - |
| dc.date.awarded | 2009. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 567662 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009672 | - |
| dc.subject.keyword | 베체트병 | - |
- Appears in Collections:
- Graduate School of Ajou University > Department of Biomedical Sciences > 3. Theses(Master)
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