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인체 편평상피 세포암 조직에서 Nrf2 에 의존한 Sulfiredoxin 과 Peroxiredoxin III의 과 발현 양상과 임상적 의의
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Young Sun | - |
| dc.date.accessioned | 2019-10-21T07:13:45Z | - |
| dc.date.available | 2019-10-21T07:13:45Z | - |
| dc.date.issued | 2010-02 | - |
| dc.identifier.other | 10432 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/17494 | - |
| dc.description | 학위논문(박사)--아주대학교 일반대학원 :의학과,2010. 2 | - |
| dc.description.tableofcontents | TABLE OF CONTENTS ABSTRACT i TABLE OF CONTENTS iii LIST OF FIGURES v ABBREVIATION vi Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 6 A. Materials 6 B. Subjects 6 C. Cell culture and viability 7 D. Transfection and depletion of siRNA 7 E. Immunocytochemistry 8 F. Co-immunoprecipitation and immunoblot analysis 8 G. Two-dimensional electrophoresis 9 H. Subcellular fractionation 10 I. Immunohistochemistry 10 J. Statistical analysis 11 Ⅲ. RESULTS 12 A. Localization of Prx III and Srx in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of Prx I and III isoforms in human lung cancer 19 F. Nrf2 dependent expression of ARE-proteins in human lung cancer 19 G. Overexpression of Srx in human lung cancer 19 H. Survival of patients with lung cancer based on Srx expression 26 I. Expression of Srx in human lung cancer tissue 26 Ⅳ. DISCUSSION 28 Ⅴ. CONCLUSION 30 REFFERENCE 32 국문요약 40 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 인체 편평상피 세포암 조직에서 Nrf2 에 의존한 Sulfiredoxin 과 Peroxiredoxin III의 과 발현 양상과 임상적 의의 | - |
| dc.title.alternative | Young Sun Kim | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Young Sun Kim | - |
| dc.contributor.department | 일반대학원 의학과 | - |
| dc.date.awarded | 2010. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 568563 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010432 | - |
| dc.subject.keyword | nrf2-Dependent Overexpression | - |
| dc.subject.keyword | sulfiredoxin | - |
| dc.subject.keyword | peroxiredoxin III | - |
| dc.subject.keyword | 인체 편평상피 세포암 조직 | - |
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- Graduate School of Ajou University > Department of Medicine > 3. Theses(Master)
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