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Special Graduate Schools
Graduate School of Science and Technology
Department of Chemical Engineering and Biotechnology
3. Theses(Master)
Povidone의 분자량에 따른 Erdosteine의 용출패턴 분석
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 변상요 | - |
| dc.contributor.author | 김영수 | - |
| dc.date.accessioned | 2019-10-21T07:12:48Z | - |
| dc.date.available | 2019-10-21T07:12:48Z | - |
| dc.date.issued | 2010-02 | - |
| dc.identifier.other | 10778 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/17325 | - |
| dc.description | 학위논문(석사)--아주대학교 산업대학원 :화학생명공학과,2010. 2 | - |
| dc.description.tableofcontents | LIST OF TABLES 07 LIST OF FIGURES 08 LIST OF PHOTOGRAPHS 09 ABSTRACT 10 제 1장 서 론 01 1. 이론적 배경 01 1-1. 개량신약의 부가가치성 02 1-2. 제제의 첨가제 및 원료 04 1-3. 제형의 설계시 용출의 중요성 03 1-4. 주원료와 결합제의 작용 06 2. 포비돈 의 용도 07 2-1. 결합제로의 사용 08 2-2. 그 외의 사용 08 2-3. 제제설계의 응용 08 제 2장 재료 및 방법 11 1. 시약 및 재료 11 2. 분자량에 따른 캡슐제제의 제조 11 3. 캡슐제제의 생체 외 방출거동 14 4. HPLC 분석 15 제 3장 결과 및 고찰 16 1. 캡슐제제의 제조 16 2. 캡슐제제의 생체 외 방출거동 16 제 4장 결 론 27 1. 포비돈 분자량과 생체 외 방출거동의 특성 27 2. 결 론 27 제 5장 참고문헌 29 제 6장 국문요약 33 | - |
| dc.language.iso | kor | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | Povidone의 분자량에 따른 Erdosteine의 용출패턴 분석 | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 산업대학원 | - |
| dc.contributor.department | 산업대학원 화학생명공학과 | - |
| dc.date.awarded | 2010. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 568271 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010778 | - |
| dc.subject.keyword | Erdosteine | - |
| dc.subject.keyword | Povidone | - |
| dc.subject.keyword | 분자량 | - |
| dc.subject.keyword | 용출패턴 | - |
| dc.description.alternativeAbstract | Povidone has been used as binder and diluent in tablet or capsulation. Studies were made to find the effect of molecular weight of povidone on the release of capsulated drugs for oral administration. Erdosteine which is a mucolytic agent and contains two blocked sulfhydryl groups that are released following its metabolic process was prepared into capsule type with povidone of various molecular weights. The dissolution rate of erdostein with povidone decreased as the molecular weight of povidone increased. We used microcrystalline cellulose as filler and magnesium sterarate as lubricant. The dissolution rate of erdostein from capsule decreased in simulated gastric fluid (pH 1.2), simulated intestinal fluid (pH 6.8), pH 4.0 and H2O as increasing K value of PVP. This study suggests that the molecular weight of pharmaceutical exipients could affect the erdostein release behavior. | - |
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