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(±)-6-epi-goniothalesdiol과 (±)-parvistone E의 입체선택적 전합성
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 이동주 | - |
| dc.contributor.author | 이량하 | - |
| dc.date.accessioned | 2019-04-01T16:42:00Z | - |
| dc.date.available | 2019-04-01T16:42:00Z | - |
| dc.date.issued | 2019--2 | - |
| dc.identifier.other | 28866 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/15166 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :약학과,2019. 2 | - |
| dc.description.tableofcontents | I. Introduction 1 II. Results and Discussions 3 III. Conclusion 8 IV. Experimentals 9 1. Materials and Methods 9 2. Experimental Procedures 10 V. References 17 VI. Appendix 19 VII. Abstracts in Korean 21 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | (±)-6-epi-goniothalesdiol과 (±)-parvistone E의 입체선택적 전합성 | - |
| dc.title.alternative | Ryangha Lee | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Ryangha Lee | - |
| dc.contributor.department | 일반대학원 약학과 | - |
| dc.date.awarded | 2019. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 905234 | - |
| dc.identifier.uci | I804:41038-000000028866 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/common/orgView/000000028866 | - |
| dc.description.alternativeAbstract | Stereoselective total synthesis of trans-2-aryl-6-alkyl tetrahydropyran (THP) natural products (±)-6-epi-goniothalesdiol A (3) and (±)-parvistone E (2) has been achieved from the readily available allylic alcohol (±)-8 in 8 and 9 steps in overall yield of 20.9% and 9.4%, respectively. A direct intramolecular oxidative cycloetherification reaction of (E)-1-aryl-5-hydroxyalkene (±)-7 promoted by 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as an oxidant proceeds via a 6-endo-trig pathway cleanly to construct the rare and challenging trans-2-aryl-6-alkyl-3,4-dihydropyran framework (±)-6 in 70% yield and with good diastereoselectivity (trans/cis = 75:25). | - |
- Appears in Collections:
- Graduate School of Ajou University > Department of Pharmacy > 3. Theses(Master)
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