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Special Graduate Schools
Graduate School of Clinical Pharmacy and Pharmaceutics
Department of Clinical Pharmacy and Pharmaceutics
3. Theses(Master)
아다팔렌과 과산화벤조일을 포함하는 겔 기반 MLE 제형의 평가
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 정이숙 | - |
| dc.contributor.author | 김한규 | - |
| dc.date.accessioned | 2019-04-01T16:40:38Z | - |
| dc.date.available | 2019-04-01T16:40:38Z | - |
| dc.date.issued | 2019-02 | - |
| dc.identifier.other | 28891 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/14912 | - |
| dc.description | 학위논문(석사)--글로벌제약임상대학원 글로벌제약임상대학원 :글로벌제약임상약학과,2019. 2 | - |
| dc.description.tableofcontents | Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 5 A. Materials 5 B. Test formulation manufacturing process 5 C. Determination of gel phase separation 6 D. Determination of gel sedimentation 6 E. Determination of gel stability 6 F. Skin permeation test (In-vitro test) 6 G. Skin irritation study (In-vivo test) 7 III. RESULTS 9 A. Determination of gel phase separation 9 B. Determination of gel sedimentation 11 C. Determination of gel stability 13 D. Skin permeation test (In-vitro test) 16 E. Skin irritation study (In-vivo test) 20 Ⅳ. DISCUSSION 23 Ⅴ. CONCLUSION 25 REFERENCES 27 국문요약 34 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | 아다팔렌과 과산화벤조일을 포함하는 겔 기반 MLE 제형의 평가 | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 글로벌제약임상대학원 | - |
| dc.contributor.department | 글로벌제약임상대학원 글로벌제약임상약학과 | - |
| dc.date.awarded | 2019. 2 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 905477 | - |
| dc.identifier.uci | I804:41038-000000028891 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/common/orgView/000000028891 | - |
| dc.description.alternativeAbstract | Acne disease is an inflammatory skin disease experienced by 70-87% of all people. Among the acne treatment methods, there are AC cure MLE Gel and Epiduo Gel which contain Adapalene which reduces sebaceous secretion and Benzoyl peroxide which shows strong antimicrobial and anti-inflammatory effect among topical treatment which is easy to carry. In this study, we compared the results of phase separation, sedimentation, stability, skin permeation and skin irritation for AC cure MLE Gel and Epiduo Gel. Unlike Epiduo Gel, which is a general water based gel, AC cure MLE Gel is manufactured using the Multi Lamella Emulsion (MLE) method, a drug delivery system technology, and has excellent pseudoceramide, skin-friendly and multi-layer lamellar structure. AC cure MLE Gel showed decreased side effects such as erythema and edema as compared with Epiduo Gel, and it was confirmed that excellent skin regeneration and skin permeation of active ingredients Adapalene and Benzoyl peroxide can be increased to increase therapeutic effect. | - |
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