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Utilization of spray-dried thermally modified rice starch as a coating material.
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 이범진 | - |
| dc.contributor.author | 정승호 | - |
| dc.date.accessioned | 2018-11-08T08:06:36Z | - |
| dc.date.available | 2018-11-08T08:06:36Z | - |
| dc.date.issued | 2014-08 | - |
| dc.identifier.other | 17633 | - |
| dc.identifier.uri | https://dspace.ajou.ac.kr/handle/2018.oak/10674 | - |
| dc.description | 학위논문(석사)--아주대학교 일반대학원 :약학,2014. 8 | - |
| dc.description.tableofcontents | CONTENTS 1. Introduction 1 2. Materials and Methods 12 2.1. Materials 12 2.2. Preparation of rice starch. 12 2.2.1. Preparation of thermally modified glutinous rice starch (TMR). 12 2.2.2. Preparation of spray-dried thermally modified glutinous rice starch (SDTMR). 13 2.3. Preparation of coating solution. 13 2.4. Preparation of film. 16 2.5. Preparation of film-coated tablets. 16 2.6. Characterization 18 2.6.1. Characterization of TMR and SDTMR. 18 2.6.1.1. pH of TMR and SDTMR. 18 2.6.1.2. Loss-on-drying (LOD) of TMR and SDTMR. 18 2.6.1.3. Particle size of TMR and SDTMR. 18 2.6.1.4 .Scanning electron microscopy (SEM). 19 2.6.1.5. Powder X-ray diffraction (PXRD). 19 2.6.1.6. Differential scanning calorimetry (DSC). 19 2.6.2. Characterization of film. 20 2.6.2.1. Mechanical properties of film by texture analyzer. 20 2.6.2.2. Roughness of film by CLSM. 20 2.7. Preparation of film-coated tablet. 21 2.8. Morphology of cross-sections of coated tablets (SEM). 23 2.9. In vitro dissolution study. 23 2.10. HPLC analysis of SarpogrelateHCl. 23 3. Results and discussion 26 3.1. Characterization of TMR and SDTMR powder. 26 3.1.1. pH of TMR and SDTMR. 26 3.1.2. Water content of TMR and SDTMR by LOD. 26 3.1.3. Particle size analysis of TMR and SDTMR by HELOS analysis. 28 3.1.4. Surface image of TMR and SDTMR by SEM. 30 3.1.5. Crystallinity of TMR and SDTMR by PXRD. 32 3.1.6. Thermodynamics of TMR and SDTMR by DSC. 34 3.2. Characterization of film. 36 3.2.1. Mechanical properties of film. 36 3.2.2. Roughness of film. 39 3.3. Characterization of coated tablet. 43 3.3.1. Appearance and cross section of coated tablet. 43 3.3.2. Physical properties of coated tablet. 45 3.3.3. Morphology of cross-section of coated tablet by SEM. 47 3.3.4. Physical properties of coated tablet (glycerol). 49 3.4. In vitro dissolution study. 51 4. Conclusions 56 5. References 57 국문초록 60 감사의글 62 Figure List Fig. 1. Chemical structures of (A) amylose and (B) amylopectin. 3 Fig. 2. Mechanism of thermal modification of rice starch. 5 Fig. 3. Mechanism of plasticizer in starch structure. 6 Fig. 4. The chemical structure of SarpogrelateHCl. 10 Fig. 5. Particle sizes of TMR and SDTMR powders. 29 Fig. 6. SEM photographs of TMR and SDTMR powders. 31 Fig. 7. PXRD diffractograms of TMR and SDTMR powders. 33 Fig. 8. DSC thermograms of TMR and SDTMR powders. 35 Fig. 9. Roughness of TMR and SDTMR films by CLSM image. 40 Fig. 10. Roughness of HPMC and SDTMR films by CLSM image. 41 Fig. 11. Appearance and cross-section of coated tablets by CLSM imaging. 44 Fig. 12. Cross-section of coated tablets by SEM image. 48 Fig. 13. Dissolution profiles of SarpogrelateHCl from coated tablets in distilled water. 53 Fig. 14. Dissolution profiles of SarpogrelateHCl from coated tablets in simulated gastric fluid (pH 1.2). 54 Fig. 15. Dissolution profiles of SarpogrelateHCl from coated tablets in simulated intestinal fluid (pH 6.8). 55 Table List Table 1. Physicochemical properties of SarpogrelateHCl. 11 Table 2. Formulation compositions for the preparation of polymeric coating solution. 15 Table 3. Formulation composition of matrix tablets. 17 Table 4. Formulation composition of matrix tablets with API. 22 Table 5. Conditions for HPLC analysis of SarpogrelateHCl. 25 Table 6. pH and LOD of TMR and SDTMR. 27 Table 7. Mechanical properties of films. 38 Table 8. Roughness index of film. 42 Table 9. Physical properties of coated tablets. 46 Table 10. Physical properties of coated tablets. 50 | - |
| dc.language.iso | eng | - |
| dc.publisher | The Graduate School, Ajou University | - |
| dc.rights | 아주대학교 논문은 저작권에 의해 보호받습니다. | - |
| dc.title | Utilization of spray-dried thermally modified rice starch as a coating material. | - |
| dc.title.alternative | Seung Ho Jung | - |
| dc.type | Thesis | - |
| dc.contributor.affiliation | 아주대학교 일반대학원 | - |
| dc.contributor.alternativeName | Seung Ho Jung | - |
| dc.contributor.department | 일반대학원 약학 | - |
| dc.date.awarded | 2014. 8 | - |
| dc.description.degree | Master | - |
| dc.identifier.localId | 652579 | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017633 | - |
| dc.subject.keyword | Glutinous rice starch | - |
| dc.subject.keyword | Thermally modified rice starch | - |
| dc.subject.keyword | Spray-dried thermally modified starch | - |
| dc.subject.keyword | Coating | - |
| dc.subject.keyword | Film | - |
| dc.description.alternativeAbstract | Spray-dried thermally modified rice starch was tested for its feasibility as a film-forming material with a sustained-release profile. Various coating formulations were prepared using PEG8000, HPC-LF and glycerol as plasticizers. Opadry-1, Opadry-2 and HPMC (with PEG8000 as a plasticizer) were used as reference coating formulations. The film-forming properties of these formulations were tested via application on OHP film and checking various parameters, including elongation, tensile strength and thickness. Tablets were coated with the above-mentioned formulations and checked for the appearance of film and morphology using CLSM imaging. Various mechanical properties of the tablets, including hardness, friability and size dimensions, were also analyzed. The results from these tests were analyzed, and the formulation containing glycerol was found to be best coating formulation amongst them. SDTMR containing glycerol was also coated on tablets with different coating weight gains of 3 %, 6 %, 9 %, 12 % and 15 %. SEM imaging and dissolution tests were performed to check morphologies and sustained release behaviors of the coated tablets. Tablets with higher coating weight gains showed gradual decreases in drug release in the beginning. In pH 1.2 media, the tablets showed significant sustained release of drug compared to uncoated tablets. However, in water and pH 6.8 media, the drug release rates increased rapidly later in testing, and the time for total drug release was similar to that of uncoated tablets. We conclude that SDTMR with glycerol as a plasticizer can be utilized as a film-forming agent. Further tests on dissolution involving transfer of undissolved tablets from pH 1.2 media to pH 6.8 is required to better understand the sustained-release properties of this film. | - |
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